The white Mr. Game & Watch represents the Num Diddly, a flat two-dimensional pixie with a white color scheme.
The stage represents PictoChat, which was released on the Nintendo DS along with Make 10: A Journey of Numbers.
The music track represents the musical theme of Brain Age 2, a mathematical game released on the Nintendo DS similar to Make 10: A Journey of Numbers.
The Dr. Kawashima Assist Trophy enemy's on-screen numbers, when added to the number 10, will feature a powerful explosion, referencing how Make 10: A Journey of Numbers is centered around the number 10.
Other trivia:
This spirit's Support type references Num Diddly's role in Make 10: A Journey of Numbers as the player's guide.
This spirit's Transformation Duration ↑ ability references how Num Diddly's pixies species can transform their faces into any number during the "Do We Make 10?" minigame.